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Mass amount of prescription bottles, horizontal In Brief
The Facts: Multiple studies have found that many adverse reactions to prescription drugs are not reported, or are under-reported.
The amount of under-reporting is very significant.
Reflect On: Why aren’t there proper adverse events reporting systems? How would proper systems and accurate numbers change health policy? What would it do to the reputation of big pharmaceutical companies if more people knew about this?
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Drug reporting systems designed to capture adverse events amongst the population have been known to be unreliable. With the rollout of COVID vaccines, adverse reactions have become a hot topic as well, mainly due to the fact that injury reporting systems for vaccines, are also known to be unreliable.
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How common is it for mild, severe or death related adverse reactions for drugs or vaccines to go unreported? An important question because without reports, researchers cannot relay important cost benefit analysis of pharmaceutical products to the general population.
A study published in 2006 in the Journal Drug Safety poured over 37 studies using a wide variety of surveillance methods from 12 different countries.They found evidence of widespread and significant under-reporting of Adverse Drug Reactions (ADRs). This includes very serious ADRs. The median under-reporting rate across the 37 studies was 94% (interquartile range 82-98%). There was no significant difference in the median under-reporting rates calculated for general practice and hospital-based studies. Five of the ten general practice studies provided evidence of a higher median under-reporting rate for all ADRs compared with more serious or severe ADRs (95% and 80%, respectively). In comparison, for five of the eight hospital-based studies the median under-reporting rate for more serious or severe ADRs remained high (95%). The median under-reporting rate was lower for 19 studies investigating specific serious/severe ADR-drug combinations but was still high at 85%. This is concerning […]
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