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The role of the gut in physical and mental health is something we are now coming to appreciate more and more.
Research is revealing in greater depth that the gut really is a “second brain”, as some like to call it, with its own autonomous nervous system which must run properly if you want to be healthy and happy. And bacteria, far from being a threat to the proper working of the gut, are in fact essential to it. Some of the trillions of bacteria living in your gut synthesize neurotransmitters that are responsible for your nerves, anxiety and euphoria. But when things go wrong and the gut flora become disturbed, for instance if a baby is born prematurely , things can take a serious turn.
Now researchers are proposing a novel high-tech solution to the problem of regulating the body’s “second brain”: genetically modified microbes that can not only detect imbalances within the gut, but also do something about them.
GM bacteria to regulate the gut
Tae Seok Moon, associate professor in the Department of Energy, Environmental & Chemical Engineering at the McKelvey School of Engineering at Washington University in St. Louis, claims to have experienced such imbalances himself.
“It is a difficult job to do,” Moon said , “to keep your neurotransmitters balanced.”
In 2017, Moon was awarded a grant to engineer a probiotic specifically aimed at protecting people from the negative health effects of adrenaline surges, and now his research has moved on to regulating the gut more generally. His method involves the creation, through genetic engineering, of a “bacterial sensor” that can detect particular chemicals in the gut. The goal is a type of modular system which will feature a variety of different sensors. He has already developed sensors for temperature, pH, oxygen levels, light, pollutants and other disease-related chemicals.
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Although Moon isn’t the first person to develop such sensors, until now they have suffered from lack of specificity, meaning that they have trouble differentiating between similarly structured molecules.
“Specificity in engineering is one of the big challenges,” Moon said. “But we have proved that this can be done.”The proof […]
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